RAS D 5000iu Vitamin D Softgel Capsule

Cholecalciferol, also known as vitamin D3, has a primary mechanism of action centered on its role in maintaining calcium homeostasis and promoting bone health. When Cholecalciferol is ingested, it undergoes two hydroxylation reactions in the body. First, it is converted to 25-hydroxyvitamin D (calcidiol) in the liver, and then further hydroxylated in the kidneys to form its active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol acts as a hormone, binding to vitamin D receptors (VDR) in various target tissues, including the intestines, kidneys, and bones. This binding activates specific genes that regulate calcium and phosphate metabolism. In the intestines, it enhances calcium and phosphate absorption, ensuring sufficient mineral levels in the blood for proper bone mineralization. Additionally, Cholecalciferol influences bone remodeling by promoting osteoclast and osteoblast activity, which are essential for maintaining bone strength and structure.

Cholecalciferol

Vitamin D Analogue

Capsule

The following are the uses of Cholecalciferol Capsule:

• Used for treating Vitamin D deficiency and related bone diseases.
• Used to prevent and treat rickets, a condition that affects bone development in children.
• Used for managing osteoporosis, helping to strengthen bones and reduce fracture risk.
• Used for individuals with malabsorption syndromes to ensure adequate Vitamin D levels.
• Used for maintaining bone health and muscle function in the elderly.
• Used to support immune function and overall well-being.
• Used as a supplement during winter months or for those with limited sun exposure.
• Used in combination with calcium to optimize bone health and prevent fractures.

The following dosage regimen is to be followed:

• Adults

The Recommended Dietary Allowance for adults is 600 IU daily

• Geriatric

The RDA for people 70 years or above is 800 IU daily

• Children

To be used as per doctor’s recommendation

In the case of an overdose of Cholecalciferol Capsules, individuals may experience symptoms such as nausea, vomiting, excessive thirst, and frequent urination. High doses can lead to elevated calcium levels in the blood, potentially causing muscle weakness, bone pain, and kidney damage. Prompt medical intervention is necessary, including supportive care and measures to reduce calcium levels. Seeking immediate medical advice is crucial to managing the effects of an overdose effectively.

In the case of a missed dose of Cholecalciferol Capsule, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication and ensure you maintain the desired vitamin D levels in your body.

To take Cholecalciferol Capsules, swallow the capsule whole with a glass of water, preferably with a meal or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided by your doctor or pharmacist.

Here are the conditions and situations when Cholecalciferol (Vitamin D3) Capsule should not be taken:

• Allergy • Should not be used in individuals with a known or suspected allergy or hypersensitivity to Cholecalciferol or any of its excipients.
• Vitamin D Toxicity • Contraindicated in patients with elevated blood calcium levels or evidence of vitamin D toxicity.
• Hypercalcemia • Not suitable for individuals with conditions that cause high calcium levels, such as primary hyperparathyroidism.
• Kidney Stones • Should be avoided in patients with a history of kidney stones or conditions that increase the risk of calcium-containing kidney stones.
• Sarcoidosis and Granuloma Disorders • Not recommended for individuals with sarcoidosis, tuberculosis, or other granulomatous diseases, as these conditions may increase vitamin D metabolism and lead to hypercalcemia.
• Hypervitaminosis D • Should not be used in patients with a history of hypervitaminosis D, a condition caused by excessive vitamin D intake.
• Infants with Cardiac Disorders • Cholecalciferol supplements should be used with caution in infants, especially those with congenital heart disease or cardiac disorders, as high doses can lead to cardiac complications.
• Certain Digestive Disorders • Not recommended for individuals with conditions that impair fat absorption, such as cystic fibrosis or Crohn’s disease, as Cholecalciferol requires fat for absorption.

The side effects of Cholecalciferol Capsule may include:

• Nausea and vomiting.
• Weakness and fatigue.
• Dry mouth.
• Loss of appetite.
• Constipation or diarrhea.
• Metallic taste in the mouth.
• Muscle or joint pain.
• Itching or rash.

Following are the precautions and warnings for Cholecalciferol Capsule:

• This medication should be used with caution in individuals with a history of kidney disease, as it can affect vitamin D metabolism and may require dosage adjustments.
• Patients with a known hypersensitivity or allergy to Cholecalciferol or any of its excipients should not take this medication.
• Regular monitoring of calcium and phosphate levels is necessary, especially in patients with a history of hypercalcemia or kidney stones.
• Cholecalciferol capsules may cause elevated calcium levels, so caution is advised when used in combination with calcium supplements or other vitamin D products.
• Patients with malabsorption syndromes or gastrointestinal disorders may require higher doses or alternative forms of vitamin D.
• It is important to maintain adequate hydration while taking Cholecalciferol capsules to reduce the risk of kidney stones.
• Pregnant and breastfeeding women should consult their healthcare provider before taking this medication, as vitamin D requirements may vary during these periods.
• Cholecalciferol capsules should be stored in a cool, dry place, protected from direct sunlight, and kept out of reach of children.

Following are the drug interactions for Cholecalciferol Capsule:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine can reduce the effectiveness of Cholecalciferol by increasing its metabolism.
• Orlistat and cholestyramine may decrease the absorption of vitamin D, potentially reducing the efficacy of Cholecalciferol.
• Thiazide diuretics can increase calcium levels, and when used with Cholecalciferol, may lead to hypercalcemia.
• Calcium channel blockers such as verapamil and diltiazem may interfere with vitamin D metabolism and reduce the effectiveness of Cholecalciferol.
• Corticosteroids like prednisone can increase vitamin D metabolism, leading to reduced vitamin D levels and potentially decreasing the efficacy of Cholecalciferol.
• Mineral oil, when taken regularly, can decrease the absorption of fat-soluble vitamins, including vitamin D, thus reducing the effectiveness of Cholecalciferol.
• Aluminum-containing antacids, when taken with Cholecalciferol, may decrease vitamin D absorption, requiring monitoring and dosage adjustments.

Following are the food interactions for Cholecalciferol Capsule:

• Consuming foods rich in vitamin D, such as fatty fish (salmon, mackerel, tuna), egg yolks, and fortified dairy products, can increase vitamin D levels in the body, and thus should be consumed in moderation to avoid excessive vitamin D intake.
• Vitamin D supplements should be taken with a meal containing fat, as it is a fat-soluble vitamin and absorption is enhanced when consumed with dietary fat.
• Avoid excessive consumption of calcium-rich foods like dairy products, leafy greens, and calcium-fortified foods, as Cholecalciferol increases calcium absorption and may lead to elevated calcium levels.
• Limit the intake of grapefruit and grapefruit juice, as they can interfere with the metabolism of vitamin D and potentially increase its levels in the blood.
• Alcohol should be consumed in moderation, as excessive alcohol intake can impair the liver’s ability to activate vitamin D, potentially affecting its effectiveness.
• Avoid high-fiber foods or fiber supplements close to taking Cholecalciferol, as fiber can bind to the vitamin and reduce its absorption.
• Certain mineral oils and orlistat (a weight-loss medication) can reduce the absorption of vitamin D and should be considered when taking Cholecalciferol.

Cholecalciferol Capsules should be stored in a cool and dry place, preferably at room temperature between 20-25°C (68-77°F). Protect the capsules from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the container tightly sealed to maintain its integrity and prevent exposure to air. It is crucial not to store the capsules in the bathroom or kitchen, as these areas can be prone to temperature fluctuations. Always check the expiration date, and do not use the medication if it is past its expiry. Dispose of any unused or expired capsules responsibly by following local pharmaceutical waste disposal guidelines or consulting a healthcare professional for guidance on safe disposal practices. Keep the medication away from children and pets to prevent accidental consumption.

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Following are the quick tips for Cholecalciferol Capsule:

• Consult your doctor for the correct dosage and duration based on your vitamin D levels and health condition.
• Take the capsule with a meal or shortly after to enhance vitamin D absorption.
• Consume the capsule with a glass of water for easy swallowing.
• Avoid taking other vitamin D supplements or multivitamins without medical advice to prevent overdose.
• If you have difficulty swallowing capsules, discuss alternative forms with your pharmacist.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your vitamin D levels as advised by your healthcare provider.
• Inform your doctor about all medications you’re taking to ensure safe usage.